美国巴克衰老研究所David Furman等研究人员，对慢性炎症在人类疾病中的影响进行了总结。 论文发表在2019年12月刊的《自然—医学》上。

研究人员表示，尽管炎症的间歇性增加对于人身伤害和感染期间的生存至关重要，但最近的研究表明，某些社会、环境和生活方式因素可以促进全身性慢性炎症（SCI），进而导致多种疾病（合起来能够代表世界范围内导致残疾和死亡的原因），例如心血管疾病、癌症、糖尿病、慢性肾脏疾病、非酒精性脂肪肝疾病以及自身免疫和神经退行性疾病。

在这一展望文章中，研究人员描述了SCI的多级机制以及增加这种损害健康表型的几种风险因素，包括感染、身体活动不足、饮食不良、环境和工业毒物以及心理压力。此外，研究人员建议了潜在的策略，以促进对SCI的早期诊断、预防和治疗。

附：英文原文

Title: Chronic inflammation in the etiology of disease across the life span

Author: David Furman, Judith Campisi, Eric Verdin, Pedro Carrera-Bastos, Sasha Targ, Claudio Franceschi, Luigi Ferrucci, Derek W. Gilroy, Alessio Fasano, Gary W. Miller, Andrew H. Miller, Alberto Mantovani, Cornelia M. Weyand, Nir Barzilai, Jorg J. Goronzy, Thomas A. Rando, Rita B. Effros, Alejandro Lucia, Nicole Kleinstreuer, George M. Slavich

Issue&Volume: 2019-12-05

Abstract: Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that collectively represent the leading causes of disability and mortality worldwide, such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease and autoimmune and neurodegenerative disorders. In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress. Furthermore, we suggest potential strategies for advancing the early diagnosis, prevention and treatment of SCI.

DOI: 10.1038/s41591-019-0675-0

Source: https://www.nature.com/articles/s41591-019-0675-0