华南理工大学刘锦斌团队报道了锰(II)引导亚纳米范围分离用于体内尺寸依赖的精确识别。相关研究成果发表在2023年1月18日出版的《德国应用化学》。

精确理解亚纳米范围内的纳米生物相互作用对于纳米医学的发展是必要的。然而，目前受到亚纳米范围内纳米颗粒尺寸控制的阻碍。

该文中，研究人员报道了一种简单的原位Mn²⁺引导离心策略，用于合成亚纳米范围内具有精确控制尺寸梯度的大规模超小金纳米颗粒（AuNPs）。随着发现[Mn(OH)]+，特别是金属锰 (Mn(0)@[Mn(OH)]+) 纳米颗粒可以通过协同配位和氢键与更大的AuNPs选择性地相互作用以形成聚集体，研究人员还实现了水溶性原子精确Au25的快速（<1小时）合成，产率高（>56%）。进一步发现，亚纳米尺寸的差异（约0.5纳米）显著改变了网状内皮系统巨噬细胞中AuNPs的非特异性吞噬作用、消除率和纳米毒理学。

附：英文原文

Title: Manganese(II)-Guided Separation in the Sub-Nanometer Regime for Precise Identification of In Vivo Size Dependence

Author: Wei Cai, Yue Tan, Kui He, Bing Tang, Jinbin Liu

Issue&Volume: 2023-01-18

Abstract: A precise understanding of nano-bio interactions in the sub-nanometer regime is necessary for advancements in nanomedicine. However, this is currently hindered by the control of the nanoparticle size in the sub-nanometer regime. Herein, we report a facile in situ Mn2+-guided centrifugation strategy for the synthesis of large-scale ultrasmall gold nanoparticles (AuNPs) with a precisely controlled size gradient at the sub-nanometer regime. With the discovery that [Mn(OH)]+, especially metallic manganese (Mn(0)@[Mn(OH)]+) nanoparticles, could selectively interact with larger AuNPs through synergistic coordination and hydrogen bonding to form aggregates, we also realized the fast (<1 h) synthesis of water-soluble atomically precise Au25 with high yields (>56%). We further demonstrated that sub-nanometer size differences (approximately 0.5 nm) significantly alter non-specific phagocytosis of AuNPs in the reticuloendothelial system macrophages, elimination rate, and nanotoxicology.

DOI: 10.1002/anie.202214720

Source: https://onlinelibrary.wiley.com/doi/10.1002/anie.202214720