美国加州大学圣迭戈分校Sheng Xu小组发现，一个完全集成的可穿戴式超声系统可用于监测移动物体的深层组织。相关论文于2023年5月22日在线发表在《自然—生物技术》杂志上。

研究人员报告了一个完全集成的自主可穿戴式超声系统（USoP）。一个小型化的柔性控制电路被设计成与超声换能器阵列连接，用于信号预处理和无线数据通信。机器学习被用来追踪移动的组织目标并协助数据解释。研究人员证明，USoP可以连续跟踪来自164毫米深的组织的生理信号。在移动受试者身上，USoP可以连续监测生理信号，包括中心血压、心率和心输出量，时间长达12小时。这一结果使深层组织信号的连续自主监测走向医疗物联网。

据介绍，可穿戴式超声技术的最新进展显示了免提数据采集的潜力，但技术障碍仍然存在，因为这些探头需要电线连接，可能会失去对移动目标的跟踪，并造成数据解释方面的挑战。

附：英文原文

Title: A fully integrated wearable ultrasound system to monitor deep tissues in moving subjects

Author: Lin, Muyang, Zhang, Ziyang, Gao, Xiaoxiang, Bian, Yizhou, Wu, Ray S., Park, Geonho, Lou, Zhiyuan, Zhang, Zhuorui, Xu, Xiangchen, Chen, Xiangjun, Kang, Andrea, Yang, Xinyi, Yue, Wentong, Yin, Lu, Wang, Chonghe, Qi, Baiyan, Zhou, Sai, Hu, Hongjie, Huang, Hao, Li, Mohan, Gu, Yue, Mu, Jing, Yang, Albert, Yaghi, Amer, Chen, Yimu, Lei, Yusheng, Lu, Chengchangfeng, Wang, Ruotao, Wang, Joseph, Xiang, Shu, Kistler, Erik B., Vasconcelos, Nuno, Xu, Sheng

Issue&Volume: 2023-05-22

Abstract: Recent advances in wearable ultrasound technologies have demonstrated the potential for hands-free data acquisition, but technical barriers remain as these probes require wire connections, can lose track of moving targets and create data-interpretation challenges. Here we report a fully integrated autonomous wearable ultrasonic-system-on-patch (USoP). A miniaturized flexible control circuit is designed to interface with an ultrasound transducer array for signal pre-conditioning and wireless data communication. Machine learning is used to track moving tissue targets and assist the data interpretation. We demonstrate that the USoP allows continuous tracking of physiological signals from tissues as deep as 164mm. On mobile subjects, the USoP can continuously monitor physiological signals, including central blood pressure, heart rate and cardiac output, for as long as 12h. This result enables continuous autonomous surveillance of deep tissue signals toward the internet-of-medical-things.

DOI: 10.1038/s41587-023-01800-0

Source: https://www.nature.com/articles/s41587-023-01800-0