厦门大学张延东团队报道了土荆皮丙酸合成的研究——自由基环化形成架桥接骨架。相关研究成果发表在2024年3月19日出版的国际学术期刊《中国化学》。

土荆皮丙酸是一类具有广泛生物活性的二萜类天然产物。它们骨架的主要结构特征是反式稠合的全氢天青，在环的连接处带有桥接的内酯。

该文中，研究人员开发了一种自由基环化策略，该策略通过衬底上不同硅取代来灵活调整环化过程。这种策略可以帮助构建一系列结构类似于土荆皮丙酸的骨架，并加快桥接内酯的构建。最后，它促进了土荆皮丙酸家族天然产物的整个骨架结构的合成，不包括B环功能化。

附：英文原文

Title: Synthetic Studies toward Pseudolaric Acids: Radical Cyclization to Form Bridged Scaffold

Author: Yujie Niu, Minggui Lin, Hao Cui, Yanji Huang, Yang Shen, Yandong Zhang

Issue&Volume: 2024-03-19

Abstract: Pseudolaric acids are a family of diterpenoid natural products that exhibit a broad spectrum of biological activities. The main structural feature of their framework is a trans-fused perhydroazulene bearing a bridged lactone positioned at the junction of the rings. Herein, we have developed a radical cyclization strategy that allows flexible tuning of the cyclization process through diverse silicon substitutions on the substrates. This strategy can assist in constructing a series of skeletons with structural resemblance to pseudolaric acids and expedites the construction of the bridged lactone. Finally, it facilitates the synthesis of the entire skeletal structure of the pseudolaric acid family of natural products, excluding the B-ring functionalization.

DOI: 10.1002/cjoc.202400085

Source: https://onlinelibrary.wiley.com/doi/full/10.1002/cjoc.202400085