美国普林斯顿大学David W. C. MacMillan团队报道了SH2自由基分选使醇-醇交叉偶联。相关研究成果发表在2024年3月22日出版的国际学术期刊《科学》。

醇类代表了一类具有无与伦比的丰富性和结构多样性的官能团类别。在一个优先考虑减少目标时间和最大限度地探索化学空间的化学合成时代，利用这些构建块进行碳-碳键形成反应是有机化学的一个关键目标。特别是，利用单一的激活模式从两个醇亚基形成新的C（sp3）–C（sp3）键，将使其能够获得非凡水平的结构多样性。

该文中报道了一种镍自由基分选介导的跨醇偶联，其中两个醇片段在一个开放的反应容器中脱氧并偶联。

附：英文原文

Title: Alcohol-alcohol cross-coupling enabled by SH2 radical sorting

Author: Ruizhe Chen, Nicholas E. Intermaggio, Jiaxin Xie, James A. Rossi-Ashton, Colin A. Gould, Robert T. Martin, Jesús Alcázar, David W. C. MacMillan

Issue&Volume: 2024-03-22

Abstract: Alcohols represent a functional group class with unparalleled abundance and structural diversity. In an era of chemical synthesis that prioritizes reducing time to target and maximizing exploration of chemical space, harnessing these building blocks for carbon-carbon bond-forming reactions is a key goal in organic chemistry. In particular, leveraging a single activation mode to form a new C(sp3)–C(sp3) bond from two alcohol subunits would enable access to an extraordinary level of structural diversity. In this work, we report a nickel radical sorting–mediated cross-alcohol coupling wherein two alcohol fragments are deoxygenated and coupled in one reaction vessel, open to air.

DOI: adl5890

Source: https://www.science.org/doi/10.1126/science.adl5890