上海交通大学医学院Yufan Wang等近日研究表明，代谢组学分析显示妊娠期糖尿病进展期间血清半胱氨酸水平下降。2024年3月1日，国际知名学术期刊《分子细胞生物学报》发表了这一成果。

在本研究中，该课题组分析了75名妊娠期糖尿病女性和75名正常糖耐量女性在整个三个月的代谢谱。课题组人员发现，在妊娠期糖尿病的发展过程中，38种代谢物的变化趋势存在显著差异。具体来说，纵向分析显示，在妊娠期糖尿病进展过程中，半胱氨酸水平显著降低。

进一步研究表明，半胱氨酸可能通过抑制磷酸烯醇丙酮酸羧激酶抑制肝脏糖异生，来减轻妊娠14.5天雌性小鼠的妊娠期糖尿病。综上所述，这些发现表明，半胱氨酸代谢途径可能在妊娠期糖尿病中发挥关键作用，补充半胱氨酸为妊娠期糖尿病患者提供潜在的新治疗策略。

研究人员表示，妊娠期糖尿病是一种与妊娠相关的代谢紊乱，可导致短期和长期的不良健康结果，但其发病机制尚不清楚。研究不同妊娠期代谢组学标志物的动态变化，可能揭示妊娠期糖尿病发展的潜在病理生理学。

附：英文原文

Title: Metabolomic profiling reveals decreased serum cysteine levels during gestational diabetes mellitus progression

Author: Lai, Mengyu, Li, Jiaomeng, Yang, Jiaying, Zhang, Qingli, Gong, Yujia, Ma, Yuhang, Fang, Fang, Li, Na, Zhai, Yingxiang, Shen, Tingting, Peng, Yongde, Liu, Jia, Wang, Yufan

Issue&Volume: 2024-03-01

Abstract: Gestational diabetes mellitus (GDM) is a pregnancy-related metabolic disorder associated with short-term and long-term adverse health outcomes, but its pathogenesis has not been clearly elucidated. Investigations of the dynamic changes in metabolomic markers in different trimesters may reveal the underlying pathophysiology of GDM progression. Therefore, in the present study, we analyzed the metabolic profiles of 75 women with GDM and 75 women with normal glucose tolerance (NGT) throughout the three trimesters. We found that the variation trends of 38 metabolites were significantly different during GDM development. Specifically, longitudinal analyses revealed that cysteine (Cys) levels significantly decreased over the course of GDM progression. Further study showed that Cys alleviated GDM in female mice at gestational day 14.5 possibly by inhibiting phosphoenolpyruvate carboxykinase to suppress hepatic gluconeogenesis. Taken together, these findings suggest that the Cys metabolic pathway might play a crucial role in GDM and that Cys supplementation represents a potential new treatment strategy for GDM patients.

DOI: 10.1093/jmcb/mjae010

Source: https://dx.doi.org/10.1093/jmcb/mjae010