研究人员利用从脑外科手术中获得的样本研究了人类颞叶皮层的网络特性。研究人员分析了2-3层锥体神经元的多神经元贴片钳记录，发现了与啮齿类动物的实质性差异。相互性呈现随机分布，突触强度与连通概率无关，颞上皮层的连通遵循有向图拓扑，且大多为非循环图拓扑。在神经元模型中应用这些原理增加了网络动力学的维度，表明大脑皮层的计算起着关键作用。
据悉，神经元网络的计算能力从根本上受到其特定连通性的制约。以前对大脑皮层连通性的研究大多是在啮齿类动物身上进行的，其中确立的原则是否也适用于演化扩展后的人类大脑皮层尚不清楚。
附：英文原文
Title: Directed and acyclic synaptic connectivity in the human layer 2-3 cortical microcircuit
Author: Yangfan Peng, Antje Bjelde, Pau Vilimelis Aceituno, Franz X. Mittermaier, Henrike Planert, Sabine Grosser, Julia Onken, Katharina Faust, Thilo Kalbhenn, Matthias Simon, Helena Radbruch, Pawel Fidzinski, Dietmar Schmitz, Henrik Alle, Martin Holtkamp, Imre Vida, Benjamin F. Grewe, Jrg R. P. Geiger
Issue&Volume: 2024-04-19
Abstract: The computational capabilities of neuronal networks are fundamentally constrained by their specific connectivity. Previous studies of cortical connectivity have mostly been carried out in rodents; whether the principles established therein also apply to the evolutionarily expanded human cortex is unclear. We studied network properties within the human temporal cortex using samples obtained from brain surgery. We analyzed multineuron patch-clamp recordings in layer 2-3 pyramidal neurons and identified substantial differences compared with rodents. Reciprocity showed random distribution, synaptic strength was independent from connection probability, and connectivity of the supragranular temporal cortex followed a directed and mostly acyclic graph topology. Application of these principles in neuronal models increased dimensionality of network dynamics, suggesting a critical role for cortical computation.
DOI: adg8828
Source: https://www.science.org/doi/10.1126/science.adg8828