近日，英国弗朗西斯-克里克研究所Caetano Reis e Sousa等研究人员合作发现，维生素D可调节依赖微生物群的癌症免疫力。相关论文于2024年4月26日发表于国际学术期刊《科学》。

研究人员发现，维生素D含量增加的小鼠对移植性癌症表现出更强的免疫依赖性抵抗力，并增强了对检查点阻断免疫疗法的反应。同样，在人类中，维生素D诱导的基因与免疫检查点抑制剂治疗反应的改善，以及对癌症的免疫力和总体存活率的提高相关。在小鼠中，抗药性可归因于维生素D对肠上皮细胞的作用，它改变了微生物组的组成，有利于脆弱拟杆菌，而脆弱拟杆菌对癌症免疫有积极的调节作用。

这些研究结果表明，维生素D、微生物共生群落和癌症免疫反应之间存在着以前未被重视的联系。总而言之，这些研究突出了维生素D水平是癌症免疫和免疫疗法成功与否的潜在决定因素。

据悉，有人认为维生素D在免疫调节和癌症中发挥作用。

附：英文原文

Title: Vitamin D regulates microbiome-dependent cancer immunity

Author: Evangelos Giampazolias, Mariana Pereira da Costa, Khiem C. Lam, Kok Haw Jonathan Lim, Ana Cardoso, Cécile Piot, Probir Chakravarty, Sonja Blasche, Swara Patel, Adi Biram, Tomas Castro-Dopico, Michael D. Buck, Richard R. Rodrigues, Gry Juul Poulsen, Susana A. Palma-Duran, Neil C. Rogers, Maria A. Koufaki, Carlos M. Minutti, Pengbo Wang, Alexander Vdovin, Bruno Frederico, Eleanor Childs, Sonia Lee, Ben Simpson, Andrea Iseppon, Sara Omenetti, Gavin Kelly, Robert Goldstone, Emma Nye, Alejandro Suárez-Bonnet, Simon L. Priestnall, James I. MacRae, Santiago Zelenay, Kiran Raosaheb Patil, Kevin Litchfield, James C. Lee, Tine Jess, Romina S. Goldszmid, Caetano Reis e Sousa

Issue&Volume: 2024-04-26

Abstract: A role for vitamin D in immune modulation and in cancer has been suggested. In this work, we report that mice with increased availability of vitamin D display greater immune-dependent resistance to transplantable cancers and augmented responses to checkpoint blockade immunotherapies. Similarly, in humans, vitamin D–induced genes correlate with improved responses to immune checkpoint inhibitor treatment as well as with immunity to cancer and increased overall survival. In mice, resistance is attributable to the activity of vitamin D on intestinal epithelial cells, which alters microbiome composition in favor of Bacteroides fragilis, which positively regulates cancer immunity. Our findings indicate a previously unappreciated connection between vitamin D, microbial commensal communities, and immune responses to cancer. Collectively, they highlight vitamin D levels as a potential determinant of cancer immunity and immunotherapy success.

DOI: adh7954

Source: https://www.science.org/doi/10.1126/science.adh7954